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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC6 All Species: 15.76
Human Site: Y901 Identified Species: 28.89
UniProt: Q03468 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q03468 NP_000115.1 1493 168416 Y901 R Q P L I T R Y N E D T S I F
Chimpanzee Pan troglodytes XP_507781 1491 168031 Y899 R Q P L I T R Y N E D T S I F
Rhesus Macaque Macaca mulatta XP_001107536 1496 168876 Y904 R Q P L I T R Y N E D T S I F
Dog Lupus familis XP_534944 1486 168108 Y896 R Q P L I T R Y N E D T S I F
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus NP_001100766 1325 148468 S768 R V L L F S Q S R Q M L H I L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508174 968 109820 V411 L T A E Q R E V Y Q N F I D S
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24368 1027 118855 W469 I L E D Y C H W R N Y N Y C R
Honey Bee Apis mellifera XP_001120586 932 107557 L375 P E K N E Q V L F C S L T E E
Nematode Worm Caenorhab. elegans P41877 1009 116656 S452 M K F K E Q G S R V L I F S Q
Sea Urchin Strong. purpuratus XP_001193315 953 107227 P396 I T K F N S D P R I F L F L L
Poplar Tree Populus trichocarpa XP_002307656 1206 134941 L648 C A V V L R D L I M P Y L L R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWY3 1057 122611 P500 V L L D K L L P K L K E R D S
Baker's Yeast Sacchar. cerevisiae P40352 1085 124509 Q528 G T L P V F Q Q Q F V I P I N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.2 83.3 N.A. N.A. 70.1 N.A. 44.6 N.A. N.A. N.A. N.A. 20 31.4 20.6 36.4
Protein Similarity: 100 99.4 97.9 89.1 N.A. N.A. 76.4 N.A. 52.2 N.A. N.A. N.A. N.A. 35.7 43.8 35.7 45.8
P-Site Identity: 100 100 100 100 N.A. N.A. 20 N.A. 0 N.A. N.A. N.A. N.A. 0 0 0 0
P-Site Similarity: 100 100 100 100 N.A. N.A. 40 N.A. 13.3 N.A. N.A. N.A. N.A. 6.6 13.3 6.6 13.3
Percent
Protein Identity: 29.4 N.A. N.A. 23.5 28.4 N.A.
Protein Similarity: 44.9 N.A. N.A. 38.2 43.9 N.A.
P-Site Identity: 0 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 20 N.A. N.A. 0 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 8 0 0 0 0 8 0 0 0 8 0 0 0 8 0 % C
% Asp: 0 0 0 16 0 0 16 0 0 0 31 0 0 16 0 % D
% Glu: 0 8 8 8 16 0 8 0 0 31 0 8 0 8 8 % E
% Phe: 0 0 8 8 8 8 0 0 8 8 8 8 16 0 31 % F
% Gly: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % H
% Ile: 16 0 0 0 31 0 0 0 8 8 0 16 8 47 0 % I
% Lys: 0 8 16 8 8 0 0 0 8 0 8 0 0 0 0 % K
% Leu: 8 16 24 39 8 8 8 16 0 8 8 24 8 16 16 % L
% Met: 8 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % M
% Asn: 0 0 0 8 8 0 0 0 31 8 8 8 0 0 8 % N
% Pro: 8 0 31 8 0 0 0 16 0 0 8 0 8 0 0 % P
% Gln: 0 31 0 0 8 16 16 8 8 16 0 0 0 0 8 % Q
% Arg: 39 0 0 0 0 16 31 0 31 0 0 0 8 0 16 % R
% Ser: 0 0 0 0 0 16 0 16 0 0 8 0 31 8 16 % S
% Thr: 0 24 0 0 0 31 0 0 0 0 0 31 8 0 0 % T
% Val: 8 8 8 8 8 0 8 8 0 8 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 31 8 0 8 8 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _